Here you'll find the most common questions in one place, organized to make each step of the process easier to understand.
We've gathered the most common questions into two groups: one for prescribers and one for patients in treatment.
Physicians and dentists who are legally licensed and registered with their professional boards.
Anvisa Resolutions RDC No. 660/2022 and RDC No. 1,015/2026. The latter is part of a package of resolutions (RDC 1,011 to 1,014/2026) that reorganized the cultivation, research and sale of medical cannabis in Brazil.
Cannabis-derived products can be prescribed by physicians or dentists licensed by their respective professional boards. No specialty or specific certification is required.
We operate under RDC No. 660/2022, which governs the importation of cannabis products by individuals for their own use, with Anvisa authorization.
The scientific literature reports evidence for medical cannabis in conditions such as chronic pain, chemotherapy-induced nausea and vomiting, multiple sclerosis spasticity, treatment-resistant epilepsy, autism spectrum disorder, insomnia and anxiety.
No. The Cannabis sativa plant contains more than 120 phytocannabinoids, such as CBD, THC (tetrahydrocannabinol), CBG, CBN and THCV.
No. Medical cannabis treatment is individualized: the dose should be titrated following the "start low, go slow" principle, with gradual adjustments until reaching the lowest effective and safe dose for each patient.
Pregnancy and breastfeeding, active psychotic disorders or a relevant family history (for products containing THC), and severe, unstable cardiovascular and/or liver disease. Each case must be assessed individually.
Cannabinoids are metabolized by cytochrome P450 enzymes (especially CYP3A4 and CYP2C19), which can change serum levels of anticoagulants, benzodiazepines, some anticonvulsants and other drugs with a narrow therapeutic index. We recommend reviewing the patient's current medications and closer clinical monitoring when starting or adjusting the dose. Cannabis-based products are contraindicated for patients taking warfarin or immunosuppressants.
Adverse reactions vary with the product's composition, the dose, individual response and the use of other medications. Reactions reported with cannabis-based products include drowsiness, sedation, dizziness, fatigue, nausea, diarrhea and changes in appetite. Products containing THC may also cause dry mouth, anxiety and temporary changes in attention, memory, perception and motor coordination, especially at higher doses.
It's a free support service for prescribers and patients: structured follow-up of dose titration and monitoring of adverse effects, adherence and clinical response, with periodic reports that support the physician's decisions without replacing the prescriber's judgment.
No. It's offered as part of our care, to support treatment safety and continuity of care.
The Direto Pharma team is available for technical and scientific support and case discussions with the prescribing professional. Contact our Pharmaceutical Care team: +55 (11) 99310-4953.
This material is for informational purposes only and does not replace individual clinical assessment or each product's current labeling and health authorization. Last updated: August 2026, based on Anvisa RDC No. 660/2022 and RDC No. 1,015/2026.
Yes. The import process for Direto Pharma products follows the rules and regulatory requirements that apply to importing cannabis-derived products for medical use into Brazil.
This timeframe covers every step needed for the product to be shipped from abroad, go through import and inspection procedures in Brazil, and be delivered to the patient's address. Direto Pharma products are manufactured in and shipped from the United States and Colombia.
No. Direto Pharma products are kept abroad and are not stored in Brazil for immediate delivery. Once the order is confirmed, the product is shipped from abroad and goes through the import process until it reaches the patient.
Direto Pharma products are manufactured in and shipped from the United States and Colombia. The shipping origin may vary depending on the product and its availability at the production site.
The import authorization is requested by the patient on the Brazilian federal government's services portal (gov.br). To make it easier, Direto Pharma offers guidance to patients who need to apply. When filling out the application, be sure to correctly enter the patient's details, the prescriber's details and the name of the company responsible for the product listed on the prescription. All information must match the prescription. Incorrect or inconsistent information may prevent the import from being cleared. If you have any questions, contact our support team.
Once your order ships, you'll receive the information you need to follow the delivery. Use the tracking code provided to check for updates directly on the Memphis Courier system. Tracking may not show new activity at every stage of the import process. During transit, inspection or clearance, it may go a few days without updates.
Each import goes through transport, inspection and clearance individually. The time for each step can vary with the workload of the authorities involved and with international logistics, so orders placed at different times may have different delivery times, even for the same product.
Not necessarily. During the import process, a package may go a few days without tracking updates, especially during transit, inspection or clearance. A lack of updates alone doesn't mean there's a problem with your order.
Inspection and clearance are carried out by the competent authorities. Direto Pharma monitors the import process but has no authority to intervene in the reviews performed by those agencies.
No. The amount quoted at the time of purchase covers the expected costs of the order, under the terms presented when you placed it. If you receive a request for an additional payment to release your package, do not pay it before contacting our team through our official channels.
Once it arrives in Brazil, the package goes through the inspection and clearance procedures that apply to imports. After that, it moves on to transport and delivery at the address provided by the patient.
Our team monitors the import process and can update you on your order status. If the delivery window is about to end or has already passed, contact us through our official support channels to check on your package.
Because this is an international purchase, with the product imported and shipped directly from abroad, a Brazilian nota fiscal is not issued as it would be for a domestic purchase. Instead, we issue a Commercial Invoice, the official document recording the international transaction, with details of the buyer, supplier, product, quantity and amount. It can be used as proof of purchase; whether your health plan accepts it for reimbursement depends on your plan's rules.
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